Triple Negative Breast Cancer Stage 4
TNBC stage 4 is a very aggressive form of breast cancer that grows & spreads more quickly than other types. “Triple-negative” means that tests showed the cancer cells lacking three things commonly found in other breast cancer cells: 1. estrogen and 2. progesterone receptors (both of which help some cancers grow), and 3. the cells don’t produce much of a protein called HER2.
Stage 4 Breast Cancer also called Metastatic Breast Cancer is when the breast cancer has spread beyond your breast and lymph nodes to other organs in your body. Tap “Watch Now” below for an easy-to-understand overview of Metastatic Breast Cancer.
- What Is Metastatic Breast Cancer?
- Understanding HR+, HER2, TNBC
Overview
When diagnosed with Stage 4 Breast Cancer, the cancer has spread beyond your breast and lymph nodes, to other organs in your body such as your lungs, bones, brain or liver, as shown here.
What Tests Will I Need and Why?
Blood and Imaging tests are done to understand your general health, confirm your diagnosis and determine your cancer stage.
Tissue analysis is also typically done to identify your cancer sub-type, which is critical to finding the best treatment option for you. The most common Breast Cancer sub-types are Hormone Receptor Positive, HER2 Positive and Triple Negative (TNBC).
You may also require special Saliva or Blood Analysis to look for specific mutations (actual changes in your body’s DNA), called BRCA1 and BRCA2.
Read this summary as often as needed and then tap, “Compare My Treatment Options Now“. Our comparison page has been created to help you understand the latest FDA-approved treatment options including, where and how the treatment will be given, what side-effects you may have and most importantly, who can help you pay for your treatment.

Cancer Research U.K. CC BY-SA 4
Your Status is critical to identifying the best treatment option for you
In addition to the size and cancer stage, your treatment options are guided by your Hormone Receptor status (+ or -) and HER2 status. Status is identified by analyzing cancer cells taken from the tumor in your breast, a procedure called a Biopsy.
Triple Negative (TNBC) (aka HER2-/HR-)
A TNBC diagnosis means that analysis of your cancer cells has shown that negative results for 3 key breast cancer “fuels”:
- Estrogen Receptors (ER)
- Progesterone Receptors (PR)
- Too much HER2 Protein
TNBC is a type of fast-growing breast cancer that occurs in about 13% of all breast cancers.
If you are diagnosed with TNBC+, it means that your treatment should include chemotherapy in most cases, and for some women Immunotherapy.
Compare your treatment options here.

Recommended Breast Cancer Videos

Stage 4 Breast Cancer
A Helpful Introduction from Dr. Jennifer Griggs

Mom Living with Metastatic Breast Cancer
A woman living with metastatic breast cancer on Long Island has survived after years of treatment.

Karen’s TNBC Story, When We Trial
Brought To You By TouchBBCA

How Cancer Spreads
Metastatic = Advanced