Active multiple myeloma is when the disease is causing noticeable symptoms and may be affecting your organs. Common symptoms include fatigue, bone pain, weakness, and infections. At this phase, the cancer cells are multiplying, so it’s important to work closely with your healthcare team to manage these symptoms and explore treatment options.
Multiple myeloma is divided into three stages based on specific blood tests and chromosome changes. Patients are also categorized as transplant candidates or non-transplant candidates, depending on their health and treatment needs.
- Overview
Overview
Stage 1 Multiple Myeloma
Beta-2-microglobulin level is lower than 3.5 mg/dL
AND
Albumin level is 3.5g/dL or higher AND Cytogenetics are considered “not high risk” AND LDH levels are normal
Stage 2 Multiple Myeloma
Not stage 1 or 3
Stage 3 Multiple Myeloma
Beta-2-microglobulin level is higher than 5.5mg/dL
AND
Cytogenetics are considered “high risk”
AND/OR
LDH levels are high
What tests will I need and Why?
Blood and Imaging tests are done to understand your general health, confirm your diagnosis and determine your cancer stage.
A bone marrow biopsy is a procedure where a small sample of bone marrow is taken, usually from your hip bone, using a thin needle. This helps doctors examine your cells and identify the type of myeloma cells present. This information is important for finding the best treatment option for you.
If your treatment team has not already performed tests to determine your cancer’s features and stage, please ask your doctor when these tests will be performed.
Re-read this summary as needed and then tap, “Compare My Treatment Options Now“. Our unique Comparison Page will help you understand your FDA-approved treatment options including, who can help you pay for your treatment, where and how each is given and what side-effects you may experience.
National Institute of Health/ treatment-active-myeloma
Recommended Multiple Myeloma Cancer Videos

Multiple Myeloma: Symptoms, Treatment, and Patient Care
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell.

What Causes Multiple Myeloma?
Learn how an abnormal growth of plasma cells can lead to the formation of multiple myeloma

How is Multiple Myeloma Diagnosed and What Testing is Necessary After?
What testing is involved in multiple myeloma diagnosis and treatment?

What Are the Beginning Stages of Multiple Myeloma (MM)?
What happens in early stages of multiple myeloma?

How is Multiple Myeloma Staged?
Watch as expert Dr. Abdullah Khan explains staging and its use, and myeloma patient and Empowerment Lead Lisa Hatfield shares how the use of staging and its factors have evolved over time.

What is Myeloma?
Find out about what myeloma is, how it starts, symptoms, and how your specialist plans the best treatment for you.